Cardiovascular (CV) illness and osteoporosis (OP) have been related to rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters together with the impact of 1-year anti-TNF remedy on these markers have been assessed so as to decide correlations between vascular pathophysiology and bone metabolism in RA and AS.
Thirty-six sufferers handled with etanercept or certolizumab pegol and 17 AS sufferers handled with ETN have been included in a 12-month follow-up examine. Bone and vascular markers have been beforehand assessed by ELISA. Bone density was measured by DXA and quantitative CT (QCT).
Circulate-mediated vasodilation (FMD), widespread carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) have been assessed by ultrasound. A number of correlation analyses indicated associations between bone and vascular markers. Osteoprotegerin, sclerostin and cathepsin Okay have been considerably related to FMD, IMT and PWV, respectively (p < 0.05).
Furthermore, complete and trabecular BMD decided by QCT inversely correlated with IMT (p < 0.05). Alternatively, amongst vascular parameters, platelet-derived progress issue BB and IMT correlated with DXA femoral and QCT complete BMD, respectively (p < 0.05). Within the RM-ANOVA evaluation, anti-TNF remedy along with baseline osteocalcin, procollagen 1 N-terminal propeptide (P1NP) or vitamin D3 ranges decided one-year modifications in IMT (p < 0.05).
Within the MANOVA evaluation, baseline illness exercise indices (DAS28, BASDAI), the one-year modifications in these indices, in addition to CRP exerted results on a number of correlations between bone and vascular markers (p < 0.05). Because the sample of interactions between bone and vascular biomarkers differed between baseline and after 12 months, anti-TNF remedy influenced these associations.
We discovered a large number of correlations in our RA and AS sufferers present process anti-TNF remedy. Among the bone markers have been related to vascular pathophysiology, whereas some vascular markers correlated with bone standing. In arthritis, systemic irritation and illness exercise might drive each vascular and bone illness.
SDF-1 α/OPF/BP Composites Improve the Migrating and Osteogenic Talents of Mesenchymal Stem Cells
In situ cell recruitment is a promising regenerative medication technique with the aim of tissue regeneration with out stem cell transplantation. This chemotaxis-based technique is aimed toward guaranteeing a restorative atmosphere by the discharge of chemokines that promote site-specific migration of therapeutic cell populations. Stromal cell-derived factor-1α (SDF-1α) is a vital chemokine that may regulate the migration of mesenchymal stem cells (MSCs).
Accordingly, right here, SDF-1α-loaded microporous oligo[poly(ethylene glycol) fumarate]/bis[2-(methacryloyloxy)ethyl] phosphate composites (SDF-1α/OPF/BP) have been engineered and probed. SDF-1α/OPF/BP composites have been loaded with escalating SDF-1α concentrations, specifically, Zero ng/ml, 50 ng/ml, 100 ng/ml, and 200 ng/ml, and have been cocultured with MSC.
Scratching assay, Transwell assay, and three-dimensional migration mannequin have been utilized to evaluate the migration response of MSCs. Immunofluorescence staining of Runx2 and osteopontin (OPN), ELISA assay of osteocalcin (OCN) and alkaline phosphatase (ALP), and Alizarin Crimson S staining have been performed to evaluate the osteogenesis of MSCs.
All SDF-1α/OPF/BP composites engendered a launch of SDF-1α (>80%) through the first 4 days. SDF-1α launched from the composites considerably promoted migration and osteogenic differentiation of MSCs documented by upregulated expression of osteogenic-related proteins, ALP, Runx2, OCN, and OPN.
SDF-1α at 100 ng/ml was optimum for enhanced migration and osteogenic proficiency. Thus, designed SDF-1α/OPF/BP composites have been competent in selling the homing and osteogenesis of MSCs and thus supply a promising bioactive scaffold candidate for on-demand bone tissue regeneration.
The Influence of Nordic Strolling on Bone Properties in Postmenopausal Girls with Pre-Diabetes and Non-Alcohol Fatty Liver Illness
This examine investigated the impression of Nordic strolling on bone properties in postmenopausal ladies with pre-diabetes and non-alcohol fatty liver illness (NAFLD). A complete of 63 eligible ladies randomly participated within the Nordic strolling coaching (AEx, n = 33), or maintained their each day way of life (Con, n = 30) throughout intervention.
Bone mineral content material (BMC) and density (BMD) of complete physique (WB), complete femur (TF), femoral neck (FN), and lumbar backbone (L2-4) have been assessed by dual-energy X-ray absorptiometry.
Serum osteocalcin, pentosidine, receptor activator of nuclear issue kappa-B ligand (RANKL) ranges have been analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BMCTF, BMDTF, BMCL2-4, and BMDL2-4, and elevated their BMCFN (p = 0.016), whereas the Con group decreased their BMCTF, BMDTF (p = 0.001), and BMDL2-4 (p = 0.002). Nonetheless, no important group × time interplay was noticed, apart from BMDL2-4 (p = 0.013).
Decreased pentosidine was correlated with elevated BMCWB(r = -0.352, p = 0.019). The intervention has no important impact on osteocalcin and RANKL. Altering of bone mass was related to altering of pentosidine, however not with osteocalcin and RANKL. Our outcomes counsel that Nordic strolling is efficient in stopping bone loss amongst postmenopausal ladies with pre-diabetes and NAFLD.
Intercourse variations within the relationship between physique composition and biomarkers of bone and fats metabolism in overweight girls and boys
Whether or not a physique mass derived from extremes of physique weight is helpful to bone stays controversial. When fats accumulation reaches extreme ranges and induces modifications in hormonal elements and adipokines, it could have an effect on bone accrual throughout progress.
This examine evaluated the relationships between physique composition and key biomarkers in relation to bone and fats metabolism in overweight Thai girls and boys. Topics aged 12-14 years have been grouped by physique mass index (BMI) and proportion of physique fats (%Fats).
Physique composition and heel bone Z-score and velocity of sound (SOS) have been assessed by bioelectrical impedance evaluation and calcaneus bone densitometry, respectively. Serum osteocalcin (OC), adiponectin, leptin, insulin, and 25 hydroxyvitamin D (25(OH)D) have been measured by ELISA. Their correlations have been analyzed and in contrast between sexes.
The outcomes confirmed that the overweight teams had no variations in imply BMIs and physique composition, besides that boys had extra muscle mass than ladies. Boys had decrease serum OC and leptin ranges than ladies. Optimistic correlations of leptin with %Fats and FM have been present in each sexes, whereas optimistic associations of %Fats with OC and insulin have been discovered solely in boys.
Bone Z-score and SOS positively correlated with OC in boys however negatively correlated with 25(OH)D in ladies. When classifying the overweight group utilizing %Fats ≥25, the optimistic correlations between %Fats and insulin and the detrimental associations between %Fats and adiponectin in ladies have been extra pronounced.
Osteocalcin (Osteocalcin) Antibody |
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| abx028306-400ul | Abbexa | 400 ul | EUR 627.6 |
Osteocalcin (Osteocalcin) Antibody |
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| abx028306-80l | Abbexa | 80 µl | EUR 343.2 |
Osteocalcin (Osteocalcin) Antibody |
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| abx031339-400ul | Abbexa | 400 ul | EUR 627.6 |
Osteocalcin (Osteocalcin) Antibody |
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| abx031339-80l | Abbexa | 80 µl | EUR 343.2 |
Osteocalcin (Osteocalcin) Antibody |
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| abx433081-200ul | Abbexa | 200 ul | EUR 343.2 |
Osteocalcin (Osteocalcin) Antibody |
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| 20-abx319643 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody |
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| abx236030-100ug | Abbexa | 100 ug | EUR 577.2 |
Osteocalcin (Osteocalcin) Antibody |
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| abx236031-100ug | Abbexa | 100 ug | EUR 610.8 |
Osteocalcin (Osteocalcin) Antibody (HRP) |
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| 20-abx108578 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody (Biotin) |
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| 20-abx105740 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody (FITC) |
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| 20-abx107158 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody Pair |
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| abx117541-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Osteocalcin (Osteocalcin) Antibody (HRP) |
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| 20-abx319644 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody (FITC) |
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| 20-abx319645 | Abbexa |
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Osteocalcin (Osteocalcin) Antibody (Biotin) |
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| 20-abx319646 | Abbexa |
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Osteocalcin |
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| MO15128 | Neuromics | 100 ul | EUR 522 |
Human Osteocalcin ELISA kit |
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| E01O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Osteocalcin ELISA kit |
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| E01O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Osteocalcin ELISA kit |
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| E01O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Osteocalcin ELISA kit |
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| E06O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Goat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Osteocalcin ELISA kit |
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| E06O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Goat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Osteocalcin ELISA kit |
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| E06O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Goat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Osteocalcin ELISA kit |
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| E08O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Canine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Osteocalcin ELISA kit |
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| E08O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Canine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Osteocalcin ELISA kit |
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| E08O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Canine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Osteocalcin ELISA kit |
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| E03O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Osteocalcin ELISA kit |
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| E03O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Osteocalcin ELISA kit |
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| E03O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Osteocalcin ELISA kit |
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| E04O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Osteocalcin ELISA kit |
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| E04O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Osteocalcin ELISA kit |
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| E04O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Osteocalcin ELISA kit |
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| E07O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Porcine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Osteocalcin ELISA kit |
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| E07O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Porcine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Osteocalcin ELISA kit |
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| E07O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Porcine Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Osteocalcin ELISA kit |
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| E02O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Osteocalcin ELISA kit |
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| E02O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Osteocalcin ELISA kit |
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| E02O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Osteocalcin ELISA kit |
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| 55R-IB79146 | Fitzgerald | 96 wells | EUR 1341.6 |
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Description: ELISA kit for the detection of Osteocalcin in the research laboratory |
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Monkey Osteocalcin ELISA kit |
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| E09O0001-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Osteocalcin ELISA kit |
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| E09O0001-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Osteocalcin ELISA kit |
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| E09O0001-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Monkey Osteocalcin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Osteocalcin (Human) ELISA Kit |
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| E4762-100 | Biovision | each | EUR 744 |
Osteocalcin (Mouse) ELISA Kit |
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| E4763-100 | Biovision | each | EUR 744 |
Osteocalcin (Rat) ELISA Kit |
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| E4764-100 | Biovision | each | EUR 744 |
Osteocalcin Antibody |
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| DF12303 | Affbiotech | 200ul | EUR 420 |
Osteocalcin Peptide |
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| 43-332P | ProSci | 0.1 mg | EUR 405.6 |
Osteocalcin antibody |
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| 61-1056 | Fitzgerald | 250 ug | EUR 457.2 |
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Description: Mouse Monoclonal Osteocalcin antibody (Biotin) |
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Osteocalcin antibody |
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| 70R-15261 | Fitzgerald | 100 ug | EUR 418.8 |
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Description: Rabbit polyclonal Osteocalcin antibody |
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Osteocalcin Antibody |
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| 39376-100ul | SAB | 100ul | EUR 468 |
Osteocalcin protein |
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| 30C-CP3015U | Fitzgerald | 20 ug | EUR 1714.8 |
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Description: Purified native Human Osteocalcin protein |
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Osteocalcin protein |
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| 30R-3286 | Fitzgerald | 100 ug | EUR 333.6 |
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Description: Purified recombinant Osteocalcin protein |
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Osteocalcin antibody |
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| 10-2408 | Fitzgerald | 250 ug | EUR 418.8 |
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Description: Mouse Monoclonal Osteocalcin antibody |
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These outcomes counsel that the associations of physique fats and bone parameters with OC, adiponectin, 25(OH)D, and insulin have been sex-specific, with larger readability when %Fats was used as an alternative of BMI to categorise weight problems.
![[Restatment. Biological management of diabetes for patients with hemoglobinopathy]](https://www.ijddc.com/erf/uploads/2021/09/2.png "[Restatment. Biological management of diabetes for patients with hemoglobinopathy]")
