Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations

Gene Panel Sequencing of Patients With Monogenic Diabetes Brings to Light Genes Typically Associated With Syndromic Presentations

Gene panel sequencing (NGS) presents the likelihood to research uncommon types of monogenic diabetes (MgD). To that finish, 18 genes had been analyzed in 1676 sufferers referred for MODY genetic testing.Among the many 307 sufferers with a molecular prognosis of MgD, 55 (17.9%) had been mutated in a gene related to a genetic syndrome.
Eight % (n=25) of the sufferers with mutations carried the m.3243A>G variant related to MIDD (Maternally inherited diabetes and deafness). At time of referral little or no had reported listening to loss or some other component of the everyday syndromic presentation.
Six % of the sufferers had been mutated in HNF1B regardless that the everyday extra-pancreatic options weren’t identified at time of referral. Surprisingly the third most distinguished etiology in these uncommon types was the WFS1 gene accounting for two.9% of the sufferers with pathogenic mutations (n=9).
None of them depicted a Wolfram syndrome presentation regardless that some options had been reported in 6/9 sufferers.Proscribing the evaluation of sure genes to sufferers with the respective particular phenotypes would miss out these with partial shows.
These outcomes subsequently underlie the undisputable good thing about NGS methods regardless that the scenario implies cascade penalties each for the molecular biologist and the clinician. Unbiased determinants of cIMT in keeping with the regression fashions had been solely gender sort of glucose monitoring and central systolic BP (cSBP).

Syntaxin Four enrichment in β-cells prevents conversion to autoimmune diabetes in non-obese diabetic (NOD) mice

Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We discovered that human sort 1 diabetic (T1D) and non-obese diabetic (NOD) mouse islets present decreased β-cell STX4 expression, in line with decreased STX4 expression as a possible driver of T1D phenotypes.
Of NOD-iβSTX4 mice, 73% had sustained normoglycemia versus <20% of management NOD (NOD-Ctrl) mice, by 25 weeks of age. At 12 weeks of age, previous to diabetes conversion, NOD-iβSTX4 mice demonstrated superior whole-body glucose tolerance and β-cell glucose responsiveness than NOD-Ctrl mice.
Greater β-cell mass and decreased β-cell apoptosis had been additionally detected in NOD-iβSTX4 pancreata in contrast with these of NOD-Ctrl mice. To check this speculation, we generated inducible β-cell-specific STX4-expressing NOD mice.
Single-cell RNA-sequencing revealed that islets from NOD-iβSTX4 had markedly decreased IFNγ signaling and TNFα signaling by way of NF-ĸB in islet β-cells, together with decreased expression of the chemokine CCL5; CD4+ Treg cells had been additionally enriched in NOD-iβSTX4 islets.
These outcomes present a deeper mechanistic understanding of STX4 perform in β-cell safety and warrant additional investigation of STX4 enrichment as a technique to reverse or forestall T1D in people or defend β-cell grafts.
This was a cross-sectional case-control examine. In complete, 192 sufferers and 188 wholesome controls had been enrolled from the Pediatric Diabetes Clinic at King Salman Navy Hospital between January 2000 and December 2010. Detailed sufferers’ information recorded whereas distributing questionnaires to regulate samples included varied gradations of consanguinity and household histories of T1DM and autoimmune illness.

No consensus was discovered within the Swedish tips for any of the 31 variables. Some tips had been contradictory. The being pregnant tips had been adopted in 17.5% of the medical data, 18.4% adopted the labor tips, and 5.3% adopted each tips. The onset of labor, mode of supply and HbA1c within the third trimester different considerably, relying on the adherence to tips.

Steady Blood Glucose Monitoring Will increase Vigorous Bodily Exercise Ranges and Is Related With Diminished Hypoglycemia Avoidance Habits In Youth With Kind 1 Diabetes

The first purpose of this examine was to discover bodily exercise (PA) ranges, hypoglycemia concern scores and hypoglycemia episodes in keeping with insulin administration and blood glucose monitoring strategies in youth with sort 1 diabetes (T1D). A self-administered questionnaire was accomplished by 28 kids and 33 adolescents with T1D, and their PA was assessed.

Hypoglycemia episodes, concern of hypoglycemia scores, insulin remedy (pump vs. injection) and blood glucose monitoring (steady blood glucose screens [CGMs] vs. blood glucose meters) strategies are reported within the current work.

There have been no vital variations within the variety of hypoglycemic episodes, little one hypoglycemia concern survey conduct or complete scores, or any elements of the PA profile between youth utilizing injections and people utilizing a pump. CGM use correlated considerably with VPA ranges (β=0.6; p=0.04).

Greater VPA ranges had been related to larger little one hypoglycemia concern survey conduct scores (β=0.52; p=0.04). The latter correlates negatively with the variety of episodes of hypoglycemia previously 12 months in all class teams. The kind of insulin injection was not related to extra exercise in youth with T1D.

In distinction, CGM use could also be related to elevated vigorous PA amongst T1D youth. These with larger hypoglycemia concern survey conduct scores engaged in additional VPA and had fewer hypoglycemia episodes. Though CGM use ensures steady monitoring of glycemia throughout train, growing hypoglycemia avoidance conduct remains to be a crucial a part of train administration methods in energetic youth with T1D.

Central Systolic Blood Strain Is Related With Early Vascular Harm in Kids and Adolescents With Kind 1 Diabetes

Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid-femoral pulse wave velocity (PWV) had been measured in kids and adolescents with T1D, in a follow-up on the outpatient clinics of Verona.

Blood strain (BP; each central and peripheral), metabolic and different cardiovascular threat components had been evaluated in multivariate linear regressions to evaluate the affiliation with the measured indices of subclinical vascular injury.

100 and twenty-six kids and adolescents had been included. cIMT was above the 95th percentile for age and top in 60.8% of the inhabitants, whereas 26% of the pattern had cDC impairment (lower than the fifth percentile) and 4.8% had an elevated PWV.

PWV was related to age, intercourse, coronary heart charge, and cSBP; cDC with age and each cSBP and, alternatively, peripheral BP (pBP). Neither pBP nor any of the examined metabolic parameters, together with glycated hemoglobin, was related to PWV and cIMT.

RRAD antibody
70R-5797 50 ug
EUR 467
Description: Rabbit polyclonal RRAD antibody raised against the middle region of RRAD
RRAD antibody
70R-5798 50 ug
EUR 467
Description: Rabbit polyclonal RRAD antibody raised against the middle region of RRAD
RRAD Antibody
37229-100ul 100ul
EUR 252
RRAD Antibody
1-CSB-PA003910
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against RRAD. Recognizes RRAD from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000
RRAD Antibody
1-CSB-PA779820
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against RRAD. Recognizes RRAD from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200
RRAD Antibody
1-CSB-PA248209
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against RRAD. Recognizes RRAD from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100
RRAD Antibody
CSB-PA233809-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against RRAD. Recognizes RRAD from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500
RRAD Antibody
CSB-PA233809-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against RRAD. Recognizes RRAD from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500
Rrad/ Rat Rrad ELISA Kit
ELI-14921r 96 Tests
EUR 886
RRAD Conjugated Antibody
C37229 100ul
EUR 397
Polyclonal RRAD Antibody
APR05556G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RRAD . This antibody is tested and proven to work in the following applications:
RRAD siRNA
20-abx932133
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.
RRAD Blocking Peptide
20-abx063234
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.
RRAD Blocking Peptide
33R-4793 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RRAD antibody, catalog no. 70R-5797
RRAD Blocking Peptide
33R-10070 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RRAD antibody, catalog no. 70R-5798
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280
RRAD ELISA KIT|Human
EF005507 96 Tests
EUR 689
Human RRAD shRNA Plasmid
20-abx954199
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.
RRAD Recombinant Protein (Human)
RP095493 100 ug Ask for price
RRAD Recombinant Protein (Rat)
RP226925 100 ug Ask for price
RRAD Recombinant Protein (Mouse)
RP169340 100 ug Ask for price
GTP-Binding Protein RAD (RRAD) Antibody
20-abx008742
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
GTP-binding protein RAD (RRAD) Antibody
20-abx324872
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.
GTP-binding protein RAD (RRAD) Antibody
20-abx214509
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
GTP-binding protein RAD (RRAD) Antibody
abx332370-100ul 100 ul
EUR 425
  • Shipped within 5-10 working days.
GTP-Binding Protein RAD (RRAD) Antibody
abx432011-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.
GTP-binding protein RAD (RRAD) Antibody
20-abx241706
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.
Polyclonal RRAD (aa36-48) Antibody (internal region)
APG00807G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human RRAD (aa36-48) (internal region). This antibody is tested and proven to work in the following applications:
RRAD ORF Vector (Human) (pORF)
ORF031832 1.0 ug DNA
EUR 405
Rrad ORF Vector (Mouse) (pORF)
ORF056448 1.0 ug DNA
EUR 506
Rrad ORF Vector (Rat) (pORF)
ORF075643 1.0 ug DNA
EUR 506
RRAD And GEM Like GTPase 2 (REM2) Antibody
abx122938-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.
RRAD And GEM Like GTPase 2 (REM2) Antibody
abx237237-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.
RRAD sgRNA CRISPR Lentivector set (Human)
K2069901 3 x 1.0 ug
EUR 339
Rrad sgRNA CRISPR Lentivector set (Mouse)
K3480701 3 x 1.0 ug
EUR 339
Rrad sgRNA CRISPR Lentivector set (Rat)
K7052701 3 x 1.0 ug
EUR 339
RRAD sgRNA CRISPR Lentivector (Human) (Target 1)
K2069902 1.0 ug DNA
EUR 154
RRAD sgRNA CRISPR Lentivector (Human) (Target 2)
K2069903 1.0 ug DNA
EUR 154
RRAD sgRNA CRISPR Lentivector (Human) (Target 3)
K2069904 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3480702 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3480703 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3480704 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Rat) (Target 1)
K7052702 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Rat) (Target 2)
K7052703 1.0 ug DNA
EUR 154
Rrad sgRNA CRISPR Lentivector (Rat) (Target 3)
K7052704 1.0 ug DNA
EUR 154
RRAD Protein Vector (Human) (pPB-C-His)
PV127326 500 ng
EUR 552
RRAD Protein Vector (Human) (pPB-N-His)
PV127327 500 ng
EUR 552
RRAD Protein Vector (Human) (pPM-C-HA)
PV127328 500 ng
EUR 552
RRAD Protein Vector (Human) (pPM-C-His)
PV127329 500 ng
EUR 552
RRAD Protein Vector (Rat) (pPB-C-His)
PV302570 500 ng
EUR 603
RRAD Protein Vector (Rat) (pPB-N-His)
PV302571 500 ng
EUR 603
RRAD Protein Vector (Rat) (pPM-C-HA)
PV302572 500 ng
EUR 603
RRAD Protein Vector (Rat) (pPM-C-His)
PV302573 500 ng
EUR 603
RRAD Protein Vector (Mouse) (pPB-C-His)
PV225790 500 ng
EUR 603
RRAD Protein Vector (Mouse) (pPB-N-His)
PV225791 500 ng
EUR 603
RRAD Protein Vector (Mouse) (pPM-C-HA)
PV225792 500 ng
EUR 603
RRAD Protein Vector (Mouse) (pPM-C-His)
PV225793 500 ng
EUR 603
Rrad 3'UTR GFP Stable Cell Line
TU168183 1.0 ml Ask for price
RRAD 3'UTR Luciferase Stable Cell Line
TU022380 1.0 ml
EUR 1394
Rrad 3'UTR Luciferase Stable Cell Line
TU118183 1.0 ml Ask for price
RRAD 3'UTR GFP Stable Cell Line
TU072380 1.0 ml
EUR 1394
Rrad 3'UTR Luciferase Stable Cell Line
TU219725 1.0 ml Ask for price
Rrad 3'UTR GFP Stable Cell Line
TU269725 1.0 ml Ask for price
Mouse GTP- binding protein RAD, Rrad ELISA KIT
ELI-14089m 96 Tests
EUR 865
Human GTP- binding protein RAD, RRAD ELISA KIT
ELI-35549h 96 Tests
EUR 824
Human GTP-binding protein RAD (RRAD) ELISA Kit
abx385354-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Mouse GTP-binding protein RAD (RRAD) ELISA Kit
abx390415-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
Rat GTP-binding protein RAD (RRAD) ELISA Kit
abx391893-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
RRAD Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
LV658369 1.0 ug DNA
EUR 514
RRAD Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV658373 1.0 ug DNA
EUR 514
RRAD Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV658374 1.0 ug DNA
EUR 514
Rrad ELISA Kit| Rat GTP-binding protein RAD ELISA Kit
EF019253 96 Tests
EUR 689
Rrad ELISA Kit| Mouse GTP-binding protein RAD ELISA Kit
EF016057 96 Tests
EUR 689
Human RRAD And GEM Like GTPase 2 (REM2) ELISA Kit
abx382769-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.
RRAD sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K2069905 3 x 1.0 ug
EUR 376
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3480705 3 x 1.0 ug
EUR 376
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K7052705 3 x 1.0 ug
EUR 376
RRAD sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K2069906 1.0 ug DNA
EUR 167
RRAD sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K2069907 1.0 ug DNA
EUR 167
RRAD sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K2069908 1.0 ug DNA
EUR 167
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3480706 1.0 ug DNA
EUR 167
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3480707 1.0 ug DNA
EUR 167
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3480708 1.0 ug DNA
EUR 167
RRAD Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
LV658370 1.0 ug DNA
EUR 514
RRAD Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV658371 1.0 ug DNA
EUR 572
RRAD Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV658372 1.0 ug DNA
EUR 572
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K7052706 1.0 ug DNA
EUR 167
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K7052707 1.0 ug DNA
EUR 167
Rrad sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K7052708 1.0 ug DNA
EUR 167
Anti-Anti-SEPT2 Antibody antibody
STJ28365 100 µl
EUR 277
Anti-Anti-SEPT7 Antibody antibody
STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-SEPT6 antibody antibody
STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Anti-Anti-SEPT2 Antibody antibody
STJ25475 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-SEPT8 Antibody antibody
STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT9 Antibody antibody
STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
Anti-Anti-SEPT11 Antibody antibody
STJ111530 100 µl
EUR 277
Anti-Anti-SEPT4 Antibody antibody
STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Anti-Anti-MARCH9 Antibody antibody
STJ112609 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ113941 100 µl
EUR 277
Anti-Anti-SEPT11 Antibody antibody
STJ114081 100 µl
EUR 277
Anti-Anti-SEPT5 Antibody antibody
STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Anti-Anti-MARCH8 Antibody antibody
STJ114828 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118549 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118550 100 µl
EUR 277
Anti-Anti-MARCH7 Antibody antibody
STJ118752 100 µl
EUR 277
Anti-Anti-SEPT3 Antibody antibody
STJ118990 100 µl
EUR 277
Anti-Anti-SEPT1 antibody antibody
STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Anti-Anti-SEPT7 Antibody antibody
STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Anti-Anti-SEPT8 Antibody antibody
STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT12 Antibody antibody
STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-DDB1 Antibody
A00333 100uL
EUR 455
Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
  • Show more
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
AEA465Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Int
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
4-AEA465Hu
  • EUR 5698.00
  • EUR 3011.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Anti-Sperm Antibody elisa. Alternative names of the recognized antigen: Anti-Spermatozoa Antibodies
  • Sperm Antibodies
  • Antisperm Antibodies
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody)
ELK8071 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antigen. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated secondary antibody. After TMB substrate soluti
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Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Anti-HAMA Antibody
E61I006 1mg
EUR 349
anti- ASH2L antibody
FNab00637 100µg
EUR 505.25
  • Immunogen: ash2(absent, small, or homeotic)-like(Drosophila)
  • Uniprot ID: Q9UBL3
  • Gene ID: 9070
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against ASH2L
anti- ASIC2 antibody
FNab00638 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: amiloride-sensitive cation channel 1, neuronal
  • Uniprot ID: Q16515
  • Gene ID: 40
  • Research Area: Neuroscience
Description: Antibody raised against ASIC2
anti- ASIC4 antibody
FNab00639 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: amiloride-sensitive cation channel 4, pituitary
  • Uniprot ID: Q96FT7
  • Gene ID: 55515
  • Research Area: Neuroscience
Description: Antibody raised against ASIC4
anti- ASK1 antibody
FNab00640 100µg
EUR 505.25
  • Recommended dilution: WB: 1:100-1:1000
  • Immunogen: mitogen-activated protein kinase kinase kinase 5
  • Uniprot ID: Q99683
  • Gene ID: 4217
  • Research Area: Immunology, Cardiovascular, Metabolism
Description: Antibody raised against ASK1
anti- ASL antibody
FNab00641 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:100-1:500
  • Immunogen: argininosuccinate lyase
  • Uniprot ID: P04424
  • Gene ID: 435
  • Research Area: Metabolism
Description: Antibody raised against ASL

A excessive proportion of early vascular injury, particularly an elevated cIMT, is current in kids and adolescents with T1D in whom cSBP appears to be a standard determinant. In kids and adolescents with T1DM, a particular focus must be on hemodynamic threat components past metabolic ones.

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