Linking Kidney and Cardiovascular Complications in Diabetes-Impact on Prognostication and Treatment: The 2019 Edwin Bierman Award Lecture

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In diabetes, rising albuminuria and reducing glomerular filtration charge are hallmarks of continual kidney illness in diabetes and improve the chance of atherosclerotic cardiovascular occasions and mortality in addition to the chance for end-stage kidney illness. For twenty years, customary of care has been controlling threat components, equivalent to glucose, blood strain, lipids, and way of life components, and particularly use of brokers blocking the renin-angiotensin system.

This has improved end result, however a big unmet want has been apparent. After many failed makes an attempt to advance the therapeutic choices, the previous few years have supplied a number of new promising remedy choices equivalent to sodium-glucose cotransporter 2 inhibitors, endothelin receptor antagonists, glucagon-like peptide 1 agonists, and nonsteroidal mineralocorticoid receptor antagonists.

The advantages and unwanted effects of those brokers exhibit the hyperlink between kidney and coronary heart; some have helpful results on each, whereas for different doubtlessly renoprotective brokers, improvement of coronary heart failure has been a limiting issue. They work on completely different pathways equivalent to hemodynamic, metabolic, inflammatory, and fibrotic targets.

We suggest that remedy could also be customized if biomarkers or physiological investigations assessing exercise in these pathways are utilized. This might doubtlessly pave the best way for precision drugs, the place remedy is optimized for maximal profit and minimal opposed outcomes. At the least it could assist prioritizing brokers for a person topic.

Low carbohydrate diets in consuming issues and kind 1 diabetes

Dietary consumption requires consideration within the remedy of each consuming issues and kind 1 diabetes (T1D) to realize optimum outcomes. Dietary administration of each situations includes encouraging all kinds of healthful meals within the context of common cultural and household traditions.

In latest instances, low carbohydrate diets have seen an increase in reputation, each in T1D and within the normal inhabitants. Low carbohydrate diets contain dietary restriction, though the extent relies on the extent of carbohydrate prescription. Though dietary restriction is a identified threat issue for consuming issues, there may be restricted literature on the affect of following a low carbohydrate food plan on the event and upkeep of consuming issues in T1D.

The purpose of this evaluation is to debate the affect of dietary restriction on the event and remedy of consuming issues and suggest issues to allow optimum well being outcomes in people with T1D, an in danger group. In an effort to obtain this, readability concerning methods that permit each flexibility in dietary consumption and facilitate wholesome consuming behaviours, while attaining glycaemic targets, are required.

Prevalence, Prevention, and Way of life Intervention of Gestational Diabetes Mellitus in China

Gestational diabetes mellitus (GDM) has change into an epidemic and has induced an incredible wholesome and financial burden in China, particularly after the “two-child coverage” put in force on October 2015.

The prevalence of GDM has continued to extend through the previous few a long time and is prone to see an extra rise sooner or later. The general public well being affect of GDM is changing into extra obvious in China and it would result in the event of continual non-communicable ailments within the long-term for each moms and their kids. Early identification of high-risk people might assist to take preventive and intervention measures to scale back the chance of GDM and opposed perinatal outcomes.

Subsequently, a give attention to prevention and intervention of GDM in China is of nice significance. Way of life interventions, together with dietary and bodily train intervention, are efficient and first-line preventive methods for GDM prevention and intervention. The GDM One-day Care Clinic established in 2011, which educates GDM sufferers on the fundamental information of GDM, dietary intervention, bodily train, weight administration, and blood glucose self-monitoring strategies, units a very good mannequin for group administration of GDM and has been carried out all through the hospitals in addition to maternal and little one well being facilities in China.

The present evaluation give attention to the prevalence, threat components, in addition to prevention and way of life intervention of GDM in China for higher understanding of the most recent epidemiology of GDM in China and assist to enhance maternal and neonatal being pregnant outcomes and promote long-term well being for ladies with GDM.

Pre-Diabetes and What It Means: The Epidemiological Proof

Prediabetes is an intermediate stage between regular glycemia and diabetes and is extremely prevalent, particularly in older age teams and overweight people. 5 completely different definitions of prediabetes are presently utilized in present observe, that are primarily based on completely different minimize factors of HbA1C, fasting glucose, and 2-h glucose.

A significant problem for the sphere is an absence of steering on when one definition may be most well-liked over one other. Dangers of main problems in individuals with prediabetes, together with diabetes, heart problems, kidney illness, and dying, additionally fluctuate relying on the prediabetes definition used. Randomized medical trials have demonstrated that way of life and pharmacologic interventions will be cost-effective, forestall diabetes, and enhance cardiovascular threat components in adults with prediabetes.

Nonetheless, the sensible implementation of way of life modification or the usage of metformin for treating prediabetes is insufficient and complex by an absence of settlement on the best way to outline the situation. Establishing consensus definitions for prediabetes needs to be a precedence and can assist inform enlargement of insurance coverage protection for way of life modification and enhance present screening and diagnostic practices.

Human Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Hu-48T 48T
EUR 441
  • Should the Human Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids.

Human Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Hu-96T 96T
EUR 570
  • Should the Human Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids.

Mouse Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Mu-48T 48T
EUR 489
  • Should the Mouse Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Mouse Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Mu-96T 96T
EUR 635
  • Should the Mouse Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Porcine Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-p-48T 48T
EUR 547
  • Should the Porcine Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Porcine Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-p-96T 96T
EUR 715
  • Should the Porcine Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Rat Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Ra-48T 48T
EUR 508
  • Should the Rat Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Rat Immunoglobulin A (IgA) ELISA Kit
DLR-IgA-Ra-96T 96T
EUR 661
  • Should the Rat Immunoglobulin A (IgA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids.

Bovine Immunoglobulin A (IgA) ELISA Kit
RD-IgA-b-48Tests 48 Tests
EUR 555

Bovine Immunoglobulin A (IgA) ELISA Kit
RD-IgA-b-96Tests 96 Tests
EUR 771

Mouse Immunoglobulin A (IgA) ELISA Kit
RD-IgA-Mu-48Tests 48 Tests
EUR 489

Mouse Immunoglobulin A (IgA) ELISA Kit
RD-IgA-Mu-96Tests 96 Tests
EUR 677

Porcine Immunoglobulin A (IgA) ELISA Kit
RD-IgA-p-48Tests 48 Tests
EUR 555

Porcine Immunoglobulin A (IgA) ELISA Kit
RD-IgA-p-96Tests 96 Tests
EUR 771

Rat Immunoglobulin A (IgA) ELISA Kit
RD-IgA-Ra-48Tests 48 Tests
EUR 511

Rat Immunoglobulin A (IgA) ELISA Kit
RD-IgA-Ra-96Tests 96 Tests
EUR 709

Bovine Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-b-48Tests 48 Tests
EUR 580

Bovine Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-b-96Tests 96 Tests
EUR 807

Chicken Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Ch-48Tests 48 Tests
EUR 534

Chicken Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Ch-96Tests 96 Tests
EUR 742

Human Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Hu-48Tests 48 Tests
EUR 455

Human Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Hu-96Tests 96 Tests
EUR 629

Mouse Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Mu-48Tests 48 Tests
EUR 511

Mouse Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Mu-96Tests 96 Tests
EUR 709

Porcine Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-p-48Tests 48 Tests
EUR 580

Porcine Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-p-96Tests 96 Tests
EUR 807

Rat Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Ra-48Tests 48 Tests
EUR 534

Rat Immunoglobulin A (IgA) ELISA Kit
RDR-IgA-Ra-96Tests 96 Tests
EUR 742

RecombiVirus Rat Epizootic diarrhea of infant mice (EDIM)/rotavirus IgA ELISA Kit, 2x96 tests
AE-300415-IgA 1 Kit
EUR 1260

Human Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative
4200-30-IGA 1 Kit
EUR 895

Mouse Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative
4210-30-IGA 1 Kit
EUR 895

Monkey Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative
4250-30-IGA 1 Kit
EUR 1017

Rat Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative
4270-30-IGA 1 Kit
EUR 895

Recombivirus? Human Anti-Zika Virus (ZIKV) NS1 protein IgA ELISA kit, 96 tests, Quantitative
RV-403300-IgA 1 Kit
EUR 1138

Mouse Anti-Meningococcal A/C/W/Y Oligosaccharides IgA (Combo) ELISA Kit, 96 tests, Quantitative
600-888-IGA 1 Kit
EUR 1017

Human Anti-Meningococcal Group A/C/W/Y Oligosaccharides IgA (Combo) ELISA Kit, 96 tests, Quantitative
600-883-IGA 1 Kit
EUR 1017

IgA
A00061 6 ml
EUR 108

IgA
A00061.0025 25 ml
EUR 252

IgA
A20061 2 ml
EUR 79

IgA/ Rat IgA ELISA Kit
ELA-E0546r 96 Tests
EUR 886

Mouse Anti-S. Pneumococcal vaccine (Pneumovax/CPS23) IgA ELISA Kit; (23 serotypes: 1, 2, 3, 4, 5, 6b, 7F, 8,9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F and 33F), 96 tests, quantitative
560-186-IGA 1 Kit
EUR 1078

Human Anti-S. Pneumococcal vaccine (Pneumovax/CPS23) IgA ELISA Kit; (23 serotypes: 1, 2, 3, 4, 5, 6b, 7F, 8,9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F and 33F), 96 tests, quantitative
560-196-IGA 1 Kit
EUR 1078

Mouse IgA
C040312-10mg 10mg
EUR 1790

Mouse IgA
C040312-1mg 1mg
EUR 607

Human IgA
C040334-10mg 10mg
EUR 1368

Human IgA
C040334-1mg 1mg
EUR 523

Human IgA
E61I009 1mg
EUR 499

Human IgA
E61I021 100ug
EUR 343

IgA Antibody
ABD8563 100 ug
EUR 438

IgA Antibody
49423-100ul 100ul
EUR 333

IgA Antibody
49423-50ul 50ul
EUR 239

IgA Antibody
45355-100ul 100ul
EUR 252

IgA Antibody
45355-50ul 50ul
EUR 187

IgA Antibody
DF8563 200ul
EUR 304
Description: IgA Antibody detects endogenous levels of total IgA.

Bovine IgA
QY-E60068 96T
EUR 426

Rabbit OVA IgA(Ovalbumin IgA) ELISA Kit
ERB0152 96T
EUR 567.6
  • Detection range: 0.391-25 ng/ml
Description: Method of detection: Indirect ELISA;Reacts with: Rabbit;Sensitivity: 0.234 ng/ml

Human Infectiousmononucleosis IgA?IM-IgA ELISA Kit
201-12-2179 96 tests
EUR 440
  • This Infectiousmononucleosis IgA?IM-IgA ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Infectiousmononucleosis IgA(IM-IgA)ELISA Kit
QY-E03999 96T
EUR 361

Rat Infectiousmononucleosis IgA(IM-IgA)ELISA Kit
QY-E10629 96T
EUR 361

Mouse Infectiousmononucleosis IgA(IM-IgA)ELISA Kit
QY-E20784 96T
EUR 361

Monkey Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx359770-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Pig Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx361672-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx363830-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Human RF-IgA(Rheumatoid Factor IgA) ELISA Kit
EH4270 96T
EUR 524.1
  • Detection range: 4.69-300IU/ml
Description: Method of detection: Indirect ELISA;Reacts with: Homo sapiens;Sensitivity: 2.813IU/ml

Mouse Pertussis virus IgA (PT IgA) ELISA Kit
abx352940-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.

Human Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx354312-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.

Mouse Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx354530-96tests 96 tests
EUR 786
  • Shipped within 5-12 working days.

Human Adenovirus (ADV) IgA (ADV IgA) ELISA Kit
abx364853-96tests 96 tests
EUR 511
  • Shipped within 5-12 working days.

Chicken Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx355867-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Human Rheumatoid Factor IgA (RF-IgA) ELISA Kit
abx257315-96tests 96 tests
EUR 637
  • Shipped within 5-12 working days.

Human Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx253446-96tests 96 tests
EUR 637
  • Shipped within 5-12 working days.

Mouse Anticardiolipin Antibody IgA (aCL IgA) ELISA Kit
abx254637-96tests 96 tests
EUR 637
  • Shipped within 5-12 working days.

Human Chlamydia pneumoniae IgA,Cpn IgA ELISA Kit
201-12-2074 96 tests
EUR 440
  • This Chlamydia pneumoniae IgA ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

ELISA kit for Human Adenovirus IgA (ADV-IgA)
KTE62701-48T 48T
EUR 332
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90?100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. Their name derives from their initial isol
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Adenovirus IgA (ADV-IgA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Adenovirus IgA (ADV-IgA)
KTE62701-5platesof96wells 5 plates of 96 wells
EUR 2115
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90?100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. Their name derives from their initial isol
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Adenovirus IgA (ADV-IgA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Adenovirus IgA (ADV-IgA)
KTE62701-96T 96T
EUR 539
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90?100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. Their name derives from their initial isol
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Adenovirus IgA (ADV-IgA) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Chlamydia pneumoniae IgA(Cpn IgA)ELISA Kit
QY-E03603 96T
EUR 361

Human Helicobacter pylori IgA(Hp-IgA) ELISA Kit
QY-E05669 96T
EUR 361

Mouse Mycoplasma pneumoniae IgA ELSA KIT(MP IgA)
QY-E21666 96T
EUR 374

IGA Conjugated Antibody
C43185 100ul
EUR 397

IgA Conjugated Antibody
C45355 100ul
EUR 397

IgA Conjugated Antibody
C49423 100ul
EUR 397

FITC-Human IgA
C050306-10ml 10ml
EUR 1368

FITC-Human IgA
C050306-1ml 1ml
EUR 269

IGA Conjugated Antibody
C35306 100ul
EUR 397

IgA Polyclonal Antibody
ES2594-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IgA from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IgA Polyclonal Antibody
ES2594-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IgA from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IgA kappa Protein
abx060686-1mg 1 mg
EUR 648
  • Shipped within 5-10 working days.

Human IgA Protein
abx060991-1mg 1 mg
EUR 370
  • Shipped within 5-10 working days.

IgA, Fc Antibody
abx023822-1mg 1 mg
EUR 551
  • Shipped within 5-10 working days.

IgA Fc Antibody
abx023823-1mg 1 mg
EUR 1094
  • Shipped within 5-10 working days.

Human IgA Antibody
abx019197-1mg 1 mg
EUR 565
  • Shipped within 5-10 working days.

IgA Polyclonal Antibody
ABP51595-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human IgA
  • Applications tips:
Description: A polyclonal antibody for detection of IgA from Human. This IgA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IgA

IgA Polyclonal Antibody
ABP51595-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human IgA
  • Applications tips:
Description: A polyclonal antibody for detection of IgA from Human. This IgA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IgA

IgA Polyclonal Antibody
ABP51595-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human IgA
  • Applications tips:
Description: A polyclonal antibody for detection of IgA from Human. This IgA antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human IgA

Human IgA Antibody
abx234075-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Human IgA Antibody
abx234076-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Anti-IgA Antibody
A07514 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for IgA Antibody (IGHA1) detection.tested for WB in Human.

Human IgA antibody
10-3151 1 mg
EUR 219
Description: Mouse Monoclonal Human IgA antibody

Human IgA antibody
10R-8448 100 ul
EUR 393
Description: Mouse monoclonal Human IgA antibody

Human IgA protein
31-AH05 5 mg
EUR 365
Description: Purified Human IgA protein

Human IgA protein
31C-CH0922 1 mg
EUR 377
Description: Purified Human IgA protein

Human IgA protein
31R-1011 1 mg
EUR 171
Description: Purified Human IgA protein

Human IgA protein
31R-1035 1 mg
EUR 177
Description: Purified Human IgA protein for use as a control or blocking reagent

Human IgA protein
31R-AI001 10 mg
EUR 560
Description: Purified Human IgA protein

IgA antibody (PE)
61R-1336 100 ug
EUR 403
Description: Rat monoclonal IgA antibody (PE)

IgA Blocking Peptide
DF8563-BP 1mg
EUR 195

Rabbit mouse IgA
PAab09894 100 ug
EUR 386

Goat human IgA
PAab09895 100 ug
EUR 386

Anti-IgA antibody
STJ93646 200 µl
EUR 197
Description: Rabbit polyclonal to IgA.

Anti-IgA antibody
STJ16101010 100 µg
EUR 354

Anti-IgA antibody
STJ16101336 1 mL
EUR 361

Anti-IgA antibody
STJ16101472 1 mL
EUR 361

Anti-IgA antibody
STJ180129 0.1 ml
EUR 212

Pig Anti-Myelin antibody IgA (AMA IgA) ELISA Kit
abx360677-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit Anti-Myelin antibody IgA (AMA IgA) ELISA Kit
abx363529-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Anticipated last on-line publication date for the Annual Evaluation of Public Well being, Quantity 42 is April 2021. Please see https://www.annualreviews.org/web page/journal/pubdates for revised estimates.

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